Without preventative vaccines and serological diagnostic tools for assay of opa, identification of jsrv based on reverse transcription polymerase chain reaction rtpcr is very important for prevention and control. Identifying the causative agent for a neoplastic disease and implications for human lung cancer the infectious etiology of chronic diseases your browsing activity is empty. Proteins overexpressed in ovine pulmonary adenocarcinoma. Ovine pulmonary adenocarcinoma opa, also known as ovine pulmonary adenomatosis, or jaagsiekte, is a chronic and contagious disease of the lungs of sheep and goats. Pulmonary adenomatosis, ovine pulmonary adenomatosis, ovine is a descriptor in the national library of medicines controlled vocabulary thesaurus, mesh medical subject headings. Advances in the study of transmissible respiratory tumours in small. Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.
Ovine pulmonary adenocarcinoma opa is a contagious, viral, neoplastic disease of the lungs of sheep and more rarely of goats. Ovine pulmonary adenocarcinoma opa is a lung tumor of sheep caused by. Retrovirusinduced ovine pulmonary adenocarcinoma, an. Opa is relatively common in ireland, where it is on the dafm list of notifiable diseases part b, although less common here than in northern ireland or the uk. Pdf retrovirusassociated neoplasms of the respiratory. Most natural cases of opa appear in animals 14 years old. Eradication programs have been based on extensive slaughtering, because no. Clinical, gross pathology, histopathology and electron microscopy of the ovine pulmonary adenocarcinoma opa, jaagsiekte either natural or experimentally induced in sheep, goat and moufflon are described. Ent is an adenocarcinoma of the secretory epithelial cells of the nasal glands and is associated with two different retroviruses. The disease has also been called jaagsiekte, after the afrikaans words for chase jaag and sickness siekte, to describe the respiratory distress observed in an animal out of breath from being chased, indicating the breathing difficulty experienced by. It is caused by a virus, known as jaagsiekte sheep retrovirus jsrv, which infects cells in the lung making them form tumours. Ovine pulmonary adenocarcinoma is caused by a virus that can be transmitted between sheep in respiratory secretions or milk. Ovine pulmonary adenocarcinoma opa is a retrovirusinduced spontaneous lung tumor of sheep that has striking analogies to some forms of human adenocarcinoma.
Ovine pulmonary adenocarcinoma results from infection by jaagsiekte sheep retrovirus jsrv, a member of the genus betaretrovirus in the retroviridae. Opa jaagsiekte moredun group moredun research institute. Ovine pulmonary adenocarcinoma opa is a transmissible lung cancer of sheep caused by jaagsiekte sheep retrovirus jsrv. These diseases can be transmitted experimentally, but do not seem to affect cattle or other. Transcriptional response of ovine lung to infection with jaagsiekte. Technical note tn684 september 2017 elec ovine pulmonary. Adenoassociated virus vector mediated expression of an oncogenic. Ovine pulmonary adenocarcinoma in slaughtered sheep. Ovine pulmonary adenocarcinoma opa national advice hub t. The disease presents itself with signs of wasting and nasal discharge, progressing to respiratory distress as the tumours take up space in the. The virus induces neoplastic transformation of secretory epithelial cells of sheep lung.
First confirmation by pcr of jaagsiekte sheep retrovirus in. The virus works by causing a proliferation of the alveolar lining cells in the lungs, causing mass amounts of fluid to be produced. Ovine pulmonary adenocarcinoma opa is a naturally occurring and experimentally inducible lung cancer of sheep caused by jaagsiekte sheep retrovirus jsrv. The etiologic agent of opa, jaagsiekte sheep retrovirus jsrv, is unique among retroviruses for having a specific tropism for the differentiated epithelial cells of the lung, and it is. Pathology of ovine pulmonary adenocarcinoma springerlink. Ovine pulmonary adenocarcinoma opa, also known as sheep pulmonary adenomatosis spa, is a naturally occurring and experimentally inducible lung cancer of sheep that shares symptomatic and histopathologic characteristics with human bronchioloalveolar carcinoma bac. It has never been cultured from infected animals, which must be identified with viral nucleic acids or antigens. These diseases can be transmitted experimentally, but do not seem to affect cattle or other animals. Ovine pulmonary adenocarcinoma iowa state university. An influx of macrophages is the predominant local immune.
Diagnosis and phylogenetic analysis of ovine pulmonary. Ovine pulmonary adenocarcinoma opa is a lung cancer strikingly similar to the pneumonictype mixed invasive adenocarcinoma with a predominant bronchioloalveolar component in humans. Experimental transmission of enzootic nasal adenocarcinoma. Embryo transfer may be used to save the genetic potential from valuable flocks that are euthanized. The major core protein p27 of the putative opc virus crossreacts with antibodies to p27. Ovine pulmonary carcinoma and enzootic nasal tumor. Jaagsiekte sheep retrovirus jsrv is a unique oncogenic virus with distinctive biological properties. Ovine pulmonary adenocarcinoma opa is a naturally occurring lung cancer of sheep caused by retrovirus infection and has several features in common with adenocarcinoma of humans, including a. Ovine pulmonary adenocarcinoma is a transmissible lung cancer of sheep. A novel translational ovine pulmonary adenocarcinoma model.
Data analysis was performed using the software tool rest 72, which. Ovine pulmonary adenocarcinoma opa, also known as jaagsiekte, is a. Mv is a slow virus infection of sheep leading to a progressing lymphoproliferative disease that affects multiple organs, but primarily the lungs, where. All content on this website, including dictionary, thesaurus, literature, geography, and other reference data is for informational purposes only. Oct 23, 20 ovine pulmonary adenocarcinoma opa is a lung tumor of sheep caused by jaagsiekte sheep retrovirus jsrv. This disease factsheet on ovine pulmonary adenocarcinoma covers the importance of the disease, aetiology, geographical distribution, species affected, transmission, clinical signs, postmortem lesions, morbidity, mortality, diagnosis, and disease control. Opa is caused by an oncogenic betaretrovirus, jaagsiekte sheep retrovirus jsrv. Ovine pulmonary adenocarcinoma was eradicated from iceland by slaughtering all sheep in affected areas. Diagnosis and prevalence of ovine pulmonary adenocarcinoma in. Ovine pulmonary adenomatosis ovine pulmonary adenocarcinoma, jaagsiekte, opa is a disease caused by jaagsiekte sheep retrovirus jsrv a member of the genus betaretrovirus. Additional resources for ovine pulmonary adenocarcinoma. Differential diagnoses of progressive pneumonia include pulmonary adenocarcinoma, pleural abscesses, and pulmonary caseous lymphadenitis. Retrovirusinduced ovine pulmonary adenocarcinoma, an animal. Opa is generally considered a chronic wasting disease with progressive respiratory distress leading to emaciation, but it may be that early lung lesions predispose to secondary bacterial pneumonia causing sudden.
Lung tumor development and spontaneous regression in lambs. Ovine pulmonary adenocarcinoma opa is a lung tumor of sheep caused by jaagsiekte sheep retrovirus jsrv. Jun 19, 2019 ovine pulmonary adenocarcinoma op a is a naturallyoccurring lung cancer that is caused by the jaagsiekte sheep retrovirus. Ultrasonographic examination is very useful to differentiate these various types of pneumonias in the live animal. This study was aimed to detect ovine pulmonary adenocarcinoma opa in sheep flocks affected with pulmonary disorders at organized farm.
Opa is caused by a retrovirus called jaagsiekte sheep retrovirus jsrv. Morbidity and mortality ovine pulmonary adenocarcinoma is rare in sheep less than 7. Telomerase activation in a model of lung adenocarcinoma. Ovine pulmonary adenocarcinoma opa is an infectious lung cancer of sheep. Ovine pulmonary adenocarcinoma opa is a contagious lung tumour of sheep resulting from infection with a betaretrovirus called jaagsiekte sheep retrovirus jsrv. Jaagsiekte, ovine pulmonary carcinoma, ovine pulmonary adenomatosis, sheep pulmonary adenomatosis ovine pulmonary adenocarcinoma is a contagious viral disease of sheep that results in pulmonary neoplasia in some animals. Enzootic nasal adenocarcinoma ena is a contagious neoplasm of the secretory epithelial cells of the nasal mucosa of sheep and goats. The oncogenic exogenous jaagsiekte sheep retrovirus jsrv, responsible for ovine pulmonary adenocarcinoma, has several endogenous counterparts termed enjsrvs. Jaagsiekte sheep retrovirus jsrv and enzootic nasal tumour virus. Bronchioloalveolar carcinoma not related to jaagsiekte. The disease is also commonly known as jaagsiekte, ovine pulmonary carcinoma, or sheep pulmonary adenomatosis.
Morbidity and mortality ovine pulmonary adenocarcinoma is rare in sheep less than 79 months of age. Characteristics of a novel lentivirus derived from south. Opa is generally considered a chronic wasting disease with progressive respiratory distress leading to emaciation, but it may be that early lung lesions predispose to secondary bacterial pneumonia causing. Ovine pulmonary adenocarcinoma opa is a contagious tumour of the lungs of sheep. Transmission of jsrv occurs predominantly through the aerosol route by inhalation of. Lung adenocarcinoma originates from retrovirus infection of. It is also commonly known as jaagsiekte, ovine pulmonary carcinoma or sheep pulmonary adenomatosis. High infection rates and disease prevalence can develop during initial infection of flocks, leading to onfarm economic losses and animal welfare issues in sheep with advanced disease. Jaagsiekte sheep retrovirus is a descriptor in the national library of medicines controlled vocabulary thesaurus, mesh medical subject headings. Jsrv is also known as the pulmonary adenomatosis virus. The disease is regarded as a valuable translational preclinical research model for studying human lung cancer, overcoming many of the limitations associated with current murine models. Opa is common in sheep, and it is most commonly observed in china.
Tumours are generally uncommon in domestic livestock, but small ruminants are unusual because two neoplastic diseases ovine pulmonary adenocarcinoma opa and enzootic nasal adenocarcinoma of sheep and goats can affect many animals in countries and flocks where they are endemic. Jsrv has been described in various breeds of sheep, rarely in goats, and does not appear to infect other animals 4, 5. Pulmonary adenomatosis, ovine is a descriptor in the national library of medicines controlled vocabulary thesaurus, mesh medical subject headings. Results also indicate that the virus has a diverse geographical.
The legacy of this great resource continues as the merck veterinary manual in the us and canada and the msd manual outside of north america. It is associated with the betaretrovirus, enzootic nasal tumor virus entv, but a causative relationship has yet to be demonstrated. Development of superficial lung lesions monitored on farm. In this study, 14dayold lambs were experimentally infected via nebulization with cellfree tumor filtrates derived from. The study of pulmonary adenomatosis, ovine has been mentioned in research publications which can be found using our bioinformatics tool below.
Jsrv is the virus that is the cause of the contagious lung tumors in sheep called ovine pulmonary adenocarcinoma opa. Interestingly, eradication of ovine pulmonary adenocarcinoma has been. Similar to visna virus and caprine arthritis encephalitis virus, this new strain induced cytopathic effects on ovine plexus choroid cultures. Pathology and pathogenesis of ovine pulmonary adenocarcinoma. Nov 07, 2001 ovine pulmonary adenocarcinoma opa is a retrovirusinduced spontaneous lung tumor of sheep that has striking analogies to some forms of human adenocarcinoma. The virus infects and transforms type ii alveolar epithelial cells and clara cells. Opa was first described in south africa in the 19th century where it was called jaagsiekte derived from the afrikaans for chasing sickness, because affected sheep have the appearance of having being chased and the. Diagnosis and control of ovine pulmonary adenocarcinoma. The clinical signs of opa comprise cachexia, moist respiratory sounds, dyspnoea and coughing that are not specific for opa. Opa is believed to be the most important disease that can.
This is the virus that killed dolly, the famous cloned ewe, at 6 years old. The first aim of this study was to monitor the development of opa with minimally invasive, realtime observations of animals experimentally infected with jsrv as well as ovine lentivirus. Ovine pulmonary adenocarcinoma opa is an infectious lung disease of sheep. Ovine pulmonary adenocarcinoma opa, caused by jaagsiekte sheep retrovirus jsrv, is characterised by the development of invariably fatal lung tumours primarily in adult sheep. Jsrv is the only virus causing a naturally occurring lung cancer ovine pulmonary adenocarcinoma, opa and possessing a major structural protein that functions as a dominant oncoprotein. It is generally found in young adult sheep, and is characterised by tumour cell growth in the lungs, with metastasis to the regional lymph nodes.
A very interesting animal model for human lung adenocarcinoma exists. The disease was first described in the late 1800s in south africa, and was named jaagsiektedriving sickness in afrikaans york and querat, 2003. The virus causes an infectious, bronchiolaralveolar lung tumour of sheep. First confirmation by pcr of jaagsiekte sheep retrovirus. The tumour cells then produce more of the virus which can infect new areas of the lung or other sheep. Ovine pulmonary adenocarcinoma opa is a contagious lung cancer of sheep previously known as sheep pulmonary adenomatosis and ovine pulmonary carcinoma. Ovine pulmonary adenocarcinoma uk lung cancer in sheep caused by a virus jaagsiekte sheep retrovirus, which is always fatal virus is spread between sheep by respiratory routes and also via colostrum and milk tips for control if you dont have it already. Ovine pulmonary adenocarcinoma opa, also known as jaagsiekte is an infectious and fatal lung disease of sheep. Pulmonary adenomatosis, ovine harvard catalyst profiles. Ovine pulmonary adenocarcinoma opa, also known as jaagsiekte or ovine pulmonary. Ovine pulmonary adenocarcinoma opa, caused by jaagsiekte sheep retrovirus. Maedivisna mv and ovine pulmonary adenocarcinoma opa are chronic diseases of retroviral aetiology that affect adult sheep and have been reported in many sheeprearing countries worldwide. Jsrv is the only virus causing a naturally occurring lung cancer ovine pulmonary adenocarcinoma, opa and possessing a major structural protein.
Research of pulmonary adenomatosis, ovine has been linked to neoplasms, adenomatosis, pulmonary, malignant neoplasm of lung, adenocarcinoma, lung neoplasms. Lung adenocarcinoma originates from retrovirus infection. First confirmation by pcr of jaagsiekte sheep retrovirus in ireland. Ovine pulmonary adenocarcinoma merck veterinary manual. Ovine pulmonary adenocarcinoma, ultrasound ovine pulmonary adenocarcinoma opa is a contagious, viral, neoplastic disease of the lungs of sheep and more rarely of goats. Progressive pneumonia in sheep and goats respiratory system. Opa is believed to be the most important disease that. Ovine pulmonary adenocarcinoma opa is a naturallyoccurring neoplastic lung disease caused by the jaagsiekte sheep retrovirus jsrv 1518. Ovine pulmonary adenocarcinoma opa, also known as ovine pulmonary adenomatosis and jaagsiekte, is a contagious neoplasm affecting the lungs of sheep, which is caused by jaagsiekte sheep retrovirus jsrv. Diagnosis and prevalence of ovine pulmonary adenocarcinoma in lung tissues of naturally infected farm sheep, veterinary world, 94. The virus replicates predominantly in the tumor cells, is released into the airways, and is found in respiratory secretions. Ovine pulmonary adenocarcinoma disease images cfsph.
Progressive pneumonia in sheep and goats respiratory. Diagnosis of ovine pulmonary adenocarcinoma daisy rankin ovine pulmonary adenocarcinoma opa is a contagious lung tumour caused by the jaagsiekte sheep retrovirus jsr. Ovine respiratory syncytial virus definition of ovine. Ovine pulmonary carcinoma opc is a contagious pulmonary neoplasia with a suspected retroviral etiology. In classical opa, the presence of oedematous fluids and copious mucoid secretions in the airways is a pathogonomic symptom. Tissue sections of sheep lung naturally affecetd by ovine pulmonary adenocarcinoma opa and unaffected sheep lung were used as positive and negative controls, respectively. A novel lentivirus was isolated from south african sheep with experimentally transmitted lung adenocarcinoma. Telomerase activity in opa and the potential involvement of the kinase akt in telomerase activation and regulation of cell proliferation were investigated. The lungs fail to deflate and are mottled with coalescing to diffuse proliferative areas pale pink with red areas of atelectasis. The disease presents itself with signs of wasting and nasal discharge, progressing to.
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